FIGURE 3 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

<p>Patterns of gene expression in the normal differentiating OE. <b>A,</b> Trajectory UMAP depicting differentiation states across pseudotime, in seven normal olfactory mucosa biopsies scRNA-seq from Durante and colleagues, 2020 and Oliva and colleagues, 2021 (<a href="#bib13 bib24" target="_blank">13, 24</a>). <b>B,</b> Heat map showing canonical cell type–specific markers for selected OE cell stages. <b>C,</b> Schematic showing that the core PRC2 protein complex can combine with either EPOP+MTF2 to form PRC2.1 or with JARID2+AEBP2 to form PRC2.2. <b>D,</b> Heat map showing PRC2 gene expression (and IDH2). (HBC: horizontal basal cell; GBC: globose basal cell; INP: immediate neuronal precursor; iOSN: immature olfactory sensory neuron; mOSN: mature olfactory sensory neuron; PRC2: Polycomb repressive complex 2).</p>