crc-21-0022_fig2.png (92.92 kB)

FIGURE 2 from The Genetic Landscape of Ocular Adnexa MALT Lymphoma Reveals Frequent Aberrations in NFAT and MEF2B Signaling Pathways

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posted on 2023-08-29, 15:20 authored by Marco Magistri, Lanie E. Happ, Jeremy Ramdial, XiaoQing Lu, Vasileios Stathias, Kranthi Kunkalla, Nitin Agarwal, Xiaoyu Jiang, Stephan C. Schürer, Sander R. Dubovy, Jennifer R. Chapman, Francisco Vega, Sandeep Dave, Izidore S. Lossos

Characterization of mutational processes. A, Heat map showing the contribution of each of the 47 COSMIC mutation signatures to each individual tumor. B, Number (top) and proportion (bottom) of mutations in each tumor that are attributed to the top 12 most prevalent signatures. C, Relative enrichment of the top 12 most prevalent signatures in the 20 most recurrently mutated genes.

Funding

HHS | NIH | National Cancer Institute (NCI)

Anthony Rizzo Families Foundation

Jaime Erin Follicular Lymphoma Research Consortium

History

ARTICLE ABSTRACT

We report systematic application of whole-exome sequencing and CN variations in OAMZL, revealing common alterations in regulation of NFAT signaling pathway that may facilitate identification of new therapies.