American Association for Cancer Research
crc-22-0489_fig1.png (537.19 kB)

FIGURE 1 from Development and Validation of a 15-gene Expression Signature with Superior Prognostic Ability in Stage II Colorectal Cancer

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posted on 2023-08-30, 14:20 authored by Matjaz Rokavec, Elif Özcan, Jens Neumann, Heiko Hermeking

Study design and workflow scheme. The analysis of six publicly available colorectal cancer patient training cohorts identified 394 genes that were significantly associated with RFS in the majority of cohorts. The 394-gene signature was computationally refined to a 61-gene signature, which showed the highest prognostic significance in the training cohorts. The 61-gene signature was validated in the in-house validation cohort and further refined to a 15-gene signature, which was then validated in additional publicly available cohorts.


Deutschen Konsortium für Translationale Krebsforschung (DKTK)



We identified and validated a 15-gene expression signature for robust prognostication and stratification of patients with stage II colorectal cancer, with superior performance when compared with currently used biomarkers. Therefore, the 15-gene expression signature has the potential to improve the prognostication and treatment decisions for patients with stage II colorectal cancer.