FIGURE 1 from Development and Validation of a 15-gene Expression Signature with Superior Prognostic Ability in Stage II Colorectal Cancer

Study design and workflow scheme. The analysis of six publicly available colorectal cancer patient training cohorts identified 394 genes that were significantly associated with RFS in the majority of cohorts. The 394-gene signature was computationally refined to a 61-gene signature, which showed the highest prognostic significance in the training cohorts. The 61-gene signature was validated in the in-house validation cohort and further refined to a 15-gene signature, which was then validated in additional publicly available cohorts.