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FIGURE 1 from A Very Long-acting Exatecan and Its Synergism with DNA Damage Response Inhibitors

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posted on 2023-05-24, 14:20 authored by Shaun D. Fontaine, Christopher W. Carreras, Ralph R. Reid, Gary W. Ashley, Daniel V. Santi

PEG-Exa remaining over time at 37°C at pH 5.0–8.4.

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ARTICLE ABSTRACT

A circulating conjugate that slowly releases Exa is described. It is efficacious after a single dose and synergistic with ATR and PARP inhibitors.

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    Cancer Research Communications

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    Keywords

    Breast CancerDna Damage And RepairDNA damageSmall Molecule AgentsTopoisomerase agentsChemotherapyCombination chemotherapyPharmacologyPharmacokinetics and pharmacodynamics

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