FIGURE 1 from A Very Long-acting Exatecan and Its Synergism with DNA Damage Response Inhibitors

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posted on 2023-05-24, 14:20 authored by Shaun D. Fontaine, Christopher W. Carreras, Ralph R. Reid, Gary W. Ashley, Daniel V. Santi

<p>PEG-Exa remaining over time at 37°C at pH 5.0–8.4.</p>

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DOI - Is supplement to A Very Long-acting Exatecan and Its Synergism with DNA Damage Response Inhibitors

ARTICLE ABSTRACT

A circulating conjugate that slowly releases Exa is described. It is efficacious after a single dose and synergistic with ATR and PARP inhibitors.

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Breast Cancer Dna Damage And Repair DNA damage Small Molecule Agents Topoisomerase agents Chemotherapy Combination chemotherapy Pharmacology Pharmacokinetics and pharmacodynamics

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