can-21-1153_table_s4_suppst4.xlsx (408.51 kB)
Table S4 from Lentiviral-Driven Discovery of Cancer Drug Resistance Mutations
dataset
posted on 2023-03-30, 14:02 authored by Paul Yenerall, Rahul K. Kollipara, Kimberley Avila, Michael Peyton, Christopher A. Eide, Daniel Bottomly, Shannon K. McWeeney, Yan Liu, Kenneth D. Westover, Brian J. Druker, John D. Minna, Ralf KittlerResults of LentiMutate on EGFRdel746-750 cDNA packaged using M-RT and osimertinib in the HCC827 cell line. Values shown are the averages of two biological replicates. The fold enrichment of "All nucleotides" is the sum of substitution rates for all nucleotides in the with doxycycline replicates divided by the sum of substitution rates for all nucleotides without doxycycline (parental) at one nucleotide position. Nucleotide w/ max error refers to the highest substitution rate for a single nucleotide at one nucleotide position.
Funding
Cancer Prevention and Research Institute of Texas (CPRIT)
National Cancer Institute (NCI)
United States Department of Health and Human Services
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