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Table S4 from Characterizing the Immune Microenvironment and Neoantigen Landscape of Hürthle Cell Carcinoma to Identify Potential Immunologic Vulnerabilities

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posted on 2023-07-31, 14:20 authored by Ian Ganly, Fengshen Kuo, Vladimir Makarov, Yiyu Dong, Ronald Ghossein, Bin Xu, Luc G.T. Morris, Timothy A. Chan

Neopeptides (9mer) associated with SNV alterations in HCC

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HHS | NIH | NCI | National Cancer Institute (NCI)

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ARTICLE ABSTRACT

The immune landscape of HCC is poorly defined and response rates to immunotherapy have not been reported. The authors found the immune microenvironment in HCC to be depleted. This immunosuppression is associated with a global LOH from haploidization and uniparental disomy, resulting in whole chromosome losses across the genome.

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Keywords

Immunotherapy Head, Neck & Oral Cancers Tumor Microenvironment Immune cells and the microenvironment Gene Technologies High-throughput sequencing Genome Biology Comparative transcriptomics Structural genomics Immunology Immune responses to cancer

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