American Association for Cancer Research

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Table S3 from Type-I Interferon Signaling Is Essential for Robust Metronomic Chemo-Immunogenic Tumor Regression in Murine Breast Cancer

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posted on 2023-04-04, 01:23 authored by Cameron Vergato, Kshama A. Doshi, Darren Roblyer, David J. Waxman

Table S3. RNAseq library sequencing stats.


U.S. Department of Defense (DOD)



Many patients with breast cancer have few therapeutic options. We show that cyclophosphamide treatment induces extensive tumor regression in a syngeneic mouse model of breast cancer via a chemo-immunogenic mechanism linked to type-I IFN production. Our findings establish that IFN signaling is essential for the robust antitumor actions of cyclophosphamide and suggest that treatment resistance may stem from silencing the IFN pathway. This suggests a new avenue for improving breast cancer treatment efficacy.