crc-22-0301-s02.xlsx (15.46 kB)

Table S2 from Genome-wide CRISPR Screen Reveals RAB10 as a Synthetic Lethal Gene in Colorectal and Pancreatic Cancers Carrying SMAD4 Loss

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posted on 2023-05-04, 14:20 authored by Hélène Erasimus, Vanessa Kolnik, Frédéric Lacroix, Sukhvinder Sidhu, Stéphane D'Agostino, Olivier Lemaitre, Alexandre Rohaut, Isabelle Sanchez, Gilbert Thill, Michel Didier, Laurent Debussche, Christophe Marcireau

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Funding

Sanofi (Sanofi US)

History

ARTICLE ABSTRACT

This study identified and validated RAB10 as new synthetic lethal gene with SMAD4. This was achieved by conducting a whole-genome CRISPR screens in different colorectal and pancreatic cell lines. A future RAB10 inhibitors could correspond to a new therapeutic solution for patients with cancer with SMAD4 deletion.

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Keywords

Gastrointestinal Cancers Colorectal cancer Pancreatic cancer Oncogenes & Tumor Suppressors Cell Signaling Guanine nucleotide binding proteins and effectors Drug Targets Gene Technologies

Licence

CC BY