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Table S12 from Proteome Analysis of Pancreatic Tumors Implicates Extracellular Matrix in Patient Outcome

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posted on 2023-04-04, 01:25 authored by Laxmi Silwal-Pandit, Stina M. Stålberg, Henrik J. Johansson, Georgios Mermelekas, Inger Marie B. Lothe, Martina L. Skrede, Astrid Marie Dalsgaard, Daniel J. H. Nebdal, Åslaug Helland, Ole Christian Lingjærde, Knut Jørgen Labori, Bjørn S. Skålhegg, Janne Lehtiö, Elin H. Kure

Univariate cox regression analysis (left) including clinical, pathological, and molecular variables. Multivariate cox regression analysis (right) including the variables with significant or trending association with patient survival in the univariate analysis.

Funding

Ministry of Health and Care Services | Helse Sør-Øst RHF (sorost)

Kreftforeningen (NCS)

Universitetet i Sørøst-Norge (USN)

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ARTICLE ABSTRACT

Pancreatic cancer lacks reliable biomarkers for prognostication and treatment of patients. We analyzed the proteome of pancreatic tumors, nonmalignant tissues of the pancreas and PDX-derived cell lines, and identified proteins that discriminate between patients with good and poor survival. The proteomics data also unraveled potential novel drug targets.

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Keywords

Gastrointestinal Cancers Pancreatic cancer Translational Research Proteomics Progression, Invasion & Metastasis Cell adhesion and extracellular matrix

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