TABLE 1 from Uncovering the Protective Neurologic Mechanisms of Hypofractionated FLASH Radiotherapy

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posted on 2023-04-27, 14:20 authored by Yasaman Alaghband, Barrett D. Allen, Eniko A. Kramár, Richard Zhang, Olivia G.G. Drayson, Ning Ru, Benoit Petit, Aymeric Almeida, Ngoc-Lien Doan, Marcelo A. Wood, Janet E. Baulch, Paola Ballesteros-Zebadua, Marie-Catherine Vozenin, Charles L. Limoli

Irradiation parameters. Fractionated whole brain irradiation was performed on the Oriatron 6e, 6-MeV electron beam LINAC at Lausanne University Hospital. Mice received three doses of 10 Gy separated by 48 hours using a 17 mm graphite applicator at either CONV (CONV-RT; 0.09 Gy/second) or ultra-high dose-rate FLASH (FLASH-RT, delivered at 5.6 × 10⁶ Gy/second in a single 1.8 μs pulse)

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HHS | NIH | National Cancer Institute (NCI)

Swiss National Science Foundation

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ARTICLE ABSTRACT

Functional preservation of cognition and LTP after hypofractionated FLASH-RT are linked to a protection of synaptic integrity and a reduction in neuroinflammation over protracted after irradiation times.

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Keywords

Radiobiology Radiation Oncology Normal tissue response to radiation Translational Research Preclinical Models Animal models of cancer

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