TABLE_1.xls (5.5 kB)

TABLE 1 from Targeting the Clear Cell Sarcoma Oncogenic Driver Fusion Gene EWSR1::ATF1 by HDAC Inhibition

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posted on 2023-07-03, 14:20 authored by Hirokazu Mae, Hidetatsu Outani, Yoshinori Imura, Ryota Chijimatsu, Akitomo Inoue, Yuki Kotani, Naohiro Yasuda, Sho Nakai, Takaaki Nakai, Satoshi Takenaka, Seiji Okada

IC₅₀s of various tumor cell lines

Funding

MEXT | Japan Society for the Promotion of Science (JSPS)

Osaka Medical Research Foundation for Intractable Diseases

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ARTICLE ABSTRACT

This study reveals the epigenetic and transcriptional suppression mechanism of the fusion oncogene EWSR1::ATF1 in clear cell sarcoma by histone deacetylase inhibitor treatment as well as identifying SOX10 as a transcription factor that regulates EWSR1::ATF1 expression.

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Keywords

Sarcomas Soft-tissue sarcoma Drug Targets Oncoprotein & tumor suppressor drug targets Oncogenes & Tumor Suppressors Oncogenes Gene Regulation Small Molecule Agents HDAC & methyltransferase inhibitors Epigenetics

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CC BY

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