American Association for Cancer Research
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TABLE 1 from Physical Activity During Adolescence and Early-adulthood and Ovarian Cancer Among Women with a BRCA1 or BRCA2 Mutation

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posted on 2023-11-28, 15:40 authored by Emma Guyonnet, Shana J. Kim, Yue Yin Xia, Vasily Giannakeas, Jan Lubinski, Susan Randall Armel, Andrea Eisen, Louise Bordeleau, Charis Eng, Olufunmilayo I. Olopade, Nadine Tung, William D. Foulkes, Fergus J. Couch, Amber M. Aeilts, Steven A. Narod, Joanne Kotsopoulos

Comparison of cases and controls with a BRCA1 or BRCA2 mutation


CCS | Canadian Cancer Society Research Institute (CCSRI)

Peter Gilgan Foundation (The Peter Gilgan Foundation)

CIHR Canada Graduate Scholarships Doctoral Award

Tier II Canada Research Chair

Sondra J and Stephen R Hardis Endowed Chair of Cancer Genomic Medicine

Tier I Canada Research Chair



In the general population, physical activity has been associated with a lower risk of several cancers; however, the evidence for ovarian cancer is not clear. It is suggested that early-life physical activity may differentially impact risk. Whether this is true among women at high risk due to a pathogenic variant (mutation) in the BRCA1 or BRCA2 genes has not been evaluated. Thus, we performed a matched case–control study to evaluate the association between adolescent and early-adulthood physical activity and ovarian cancer. BRCA mutation carriers who completed a research questionnaire on various exposures and incident disease and with data available on physical activity were eligible for inclusion. Self-reported activity at ages 12–13, 14–17, 18–22, 23–29, and 30–34 was used to calculate the average metabolic equivalent of task (MET)-hours/week for moderate, vigorous, and total physical activity during adolescence (ages 12–17) and early-adulthood (ages 18–34). Conditional logistic regression was used to estimate the OR and 95% confidence intervals (CI) of invasive ovarian cancer associated with physical activity. This study included 215 matched pairs (mean age = 57.3). There was no association between total physical activity during adolescence (ORhigh vs. low = 0.91; 95% CI: 0.61–1.36; Ptrend = 0.85), early-adulthood (ORhigh vs. low = 0.78; 95% CI: 0.51–1.20; Ptrend = 0.38) and overall (ORhigh vs. low = 0.81; 95% CI: 0.54–1.23; Ptrend = 0.56) and ovarian cancer. Findings were similar for moderate (Ptrend ≥ 0.25) and vigorous (Ptrend ≥ 0.57) activity. These findings do not provide evidence for an association between early-life physical activity and BRCA-ovarian cancer; however, physical activity should continue to be encouraged to promote overall health. In this matched case–control study, we observed no association between physical activity during adolescence or early-adulthood and subsequent risk of ovarian cancer. These findings do not provide evidence for an association between early-life physical activity and BRCA-ovarian cancer; however, being active remains important to promote overall health and well-being.