Supplementary Tables 1-6 from Uterine Lavage Identifies Cancer Mutations and Increased <i>TP53</i> Somatic Mutation Burden in Individuals with Ovarian Cancer
posted on 2023-04-04, 01:40authored byTalayeh S. Ghezelayagh, Brendan F. Kohrn, Jeanne Fredrickson, Enna Manhardt, Marc R. Radke, Ronit Katz, Heidi J. Gray, Renata R. Urban, Kathryn P. Pennington, John B. Liao, Kemi M. Doll, Elise J. Simons, Jennifer K. Burzawa, Barbara A. Goff, Paul Speiser, Elizabeth M. Swisher, Barbara M. Norquist, Rosa Ana Risques
<p>Table S1. Clinical patient information</p><p>Table S2. Duplex Sequencing gene targets</p><p>Table S3. Custom probes for hotspots</p><p>Table S4. Mutation Frequency and Mutation Burden by patient and gene</p><p>Table S5. Codons most frequently mutated in ovarian cancers</p><p>Table S6. List of coding mutations by patient and gene</p>
Cancer driver mutations are found in uterine lavage DNA in all individuals, but driver TP53 mutations presented as significantly larger clones and with higher frequency in lavages from individuals with ovarian cancer. This suggests that TP53-specific clonal expansion plays a role in tumorigenesis and presents opportunities for early detection.