- No file added yet -

Supplementary Tables 1-6 from Uterine Lavage Identifies Cancer Mutations and Increased TP53 Somatic Mutation Burden in Individuals with Ovarian Cancer

dataset

posted on 2023-04-04, 01:40 authored by Talayeh S. Ghezelayagh, Brendan F. Kohrn, Jeanne Fredrickson, Enna Manhardt, Marc R. Radke, Ronit Katz, Heidi J. Gray, Renata R. Urban, Kathryn P. Pennington, John B. Liao, Kemi M. Doll, Elise J. Simons, Jennifer K. Burzawa, Barbara A. Goff, Paul Speiser, Elizabeth M. Swisher, Barbara M. Norquist, Rosa Ana Risques

Table S1. Clinical patient information

Table S2. Duplex Sequencing gene targets

Table S3. Custom probes for hotspots

Table S4. Mutation Frequency and Mutation Burden by patient and gene

Table S5. Codons most frequently mutated in ovarian cancers

Table S6. List of coding mutations by patient and gene

Funding

HHS | National Institutes of Health (NIH)

Rivkin Center for Ovarian Cancer (RivkinCenter)

HHS | NIH | National Cancer Institute (NCI)

Minnesota Ovarian Cancer Alliance (MOCA)

History

ARTICLE ABSTRACT

Cancer driver mutations are found in uterine lavage DNA in all individuals, but driver TP53 mutations presented as significantly larger clones and with higher frequency in lavages from individuals with ovarian cancer. This suggests that TP53-specific clonal expansion plays a role in tumorigenesis and presents opportunities for early detection.

Usage metrics

Keywords

Gynecological Cancers Ovarian cancer Biomarkers Cancer risk biomarkers Early detection biomarkers Tumor Evolution Oncogenes & Tumor Suppressors p53 Gene Technologies High-throughput sequencing Comparative genomics

Licence

CC BY

Exports

RefWorks

BibTeX

Ref. manager

Endnote

DataCite

NLM