Supplementary Tables3-5,7-9 from Expression Levels of Therapeutic Targets as Indicators of Sensitivity to Targeted Therapeutics

Supplementary Table 3a: Molecular Targets of the Anticancer Drugs from GDSC, CTRP and DrugBank. Spearman correlation and permutation testing results are provided for both the GDSC and CTRP datasets. Supplementary Table 4: List of drugs where we observe both a correlated and an anti-correlated target in GDSC and CRTP datasets. Supplementary Table 5: Fractions of single cells in each cell line expressing both targets from Figure 3. Supplementary Table 7: Transcript isoform aware reanalysis of CTRP-GDSC concordance. Spearman correlation values between drug sensitivity and drug-target transcript isoforms expression for 74 drugs common between GDSC and CTRP. The 541 cell lines common in GDSC and CTRP where drug-target transcript isoform expression and AUC values could be obtained were considered. As GDSC and CTRP provide gene-level expression measurements from different microarray versions (Affymetrix GeneChip HG-U133A in GDSC and HG-U133PLUS2 in CTRP), which potentially detect different isoforms of each gene, we repeated our analysis at the transcript level. Supplementary Table 8: The top 20 strongest correlations and top 20 strongest anti-correlations between drug sensitivity and gene expression for the GDSC and CTRP datasets. Supplementary Table 9: Drug-target pairs that are significantly correlated in cell lines derived from a cancer subtype but not significantly correlated in the pan-cancer analysis.