Supplementary Table S7 from Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma

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posted on 2025-03-07, 16:00 authored by Megan E. Bischoff, Behrouz Shamsaei, Juechen Yang, Dina Secic, Bhargav Vemuri, Julie A. Reisz, Angelo D’Alessandro, Caterina Bartolacci, Rafal Adamczak, Lucas Schmidt, Jiang Wang, Amelia Martines, Jahnavi Venkat, Vanina Toffessi Tcheuyap, Jacek Biesiada, Catherine A. Behrmann, Katherine E. Vest, James Brugarolas, Pier Paolo Scaglioni, David R. Plas, Krushna C. Patra, Shuchi Gulati, Julio A. Landero Figueroa, Jarek Meller, John T. Cunningham, Maria F. Czyzyk-Krzeska

Genes expressed in spatial clusters

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National Cancer Institute (NCI)

United States Department of Health and Human Services

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National Institute of General Medical Sciences (NIGMS)

United States Department of Health and Human Services

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ARTICLE ABSTRACT

The work establishes a requirement for glucose-dependent coordination between energy production and redox homeostasis, which is fundamental for the survival of cancer cells that accumulate Cu and contributes to tumor growth.

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Keywords

Genitourinary Cancers Renal cancer Metabolism Metabolic pathways Mitochondrial function Progression, Invasion & Metastasis Tumor progression Single Cell Technologies Tumor Evolution

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