Supplementary Table S5 from Blocking Tryptophan Catabolism Reduces Triple-Negative Breast Cancer Invasive Capacity

Name: Supplementary Table S5 from Blocking Tryptophan Catabolism Reduces Triple-Negative Breast Cancer Invasive Capacity
Published: 2024-10-17T13:40:16+00:00
License: https://creativecommons.org/licenses/by/4.0/
Keywords: cancer

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posted on 2024-10-17, 13:40 authored by Li-Wei Kuo, Lyndsey S. Crump, Kathleen O’Neill, Michelle M. Williams, Jessica L. Christenson, Nicole S. Spoelstra, Micaela Kalani Roy, Amy Argabright, Julie A. Reisz, Angelo D’Alessandro, Meher P. Boorgula, Andrew Goodspeed, Mike Bickerdike, Benjamin G. Bitler, Jennifer K. Richer

<p>Differential gene expression list of Bulk RNA-seq for BT549 (under suspension condition) treated with AT-0174 vs. Vehicle</p>

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DOI - Is supplement to Blocking Tryptophan Catabolism Reduces Triple-Negative Breast Cancer Invasive Capacity

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TDO2 is more highly expressed than the nonhomologous TRP-catabolizing enzyme IDO1 in TNBC. We find that TDO2 knockdown can lead to a compensatory increase in IDO1. Therefore, we tested a newly developed TDO2/IDO1 dual inhibitor and found that it decreases TRP catabolism, anchorage-independent survival, and invasive capacity.

Supplementary Table S5 from Blocking Tryptophan Catabolism Reduces Triple-Negative Breast Cancer Invasive Capacity

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