American Association for Cancer Research
crc-23-0009-s02.xlsx (21.76 MB)

Supplementary Table S2 from Whole-genome CpG-resolution DNA Methylation Profiling of HNSCC Reveals Distinct Mechanisms of Carcinogenesis for Fine-scale HPV+ Cancer Subtypes

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posted on 2023-08-30, 14:20 authored by Tingting Qin, Shiting Li, Leanne E. Henry, Elysia Chou, Raymond G. Cavalcante, Bailey F. Garb, Nisha J. D'Silva, Laura S. Rozek, Maureen A. Sartor

RNA and DNA methylation Gene Set Enrichment results


HHS | NIH | National Cancer Institute (NCI)



This study revealed that the previously observed hypermethylation of HPV(+) HNSCC is due solely to the IMU subtype, illustrating the importance of fine-scale subtype analysis in such a heterogeneous disease. Particularly, IMU has significantly higher methylation of transposable elements, which can be tested as a prognosis biomarker in future translational studies.