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Supplementary Table S1 from Nucleophosmin plays a role in repairing DNA damage and is a target for cancer treatment

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posted on 2024-09-16, 09:53 authored by Konjeti R. Sekhar, Michael L. Freeman

The relationship between cancer cell line viability and NPM1 dependency, determined from genome-wide CRISPR-Cas9 screens (https://depmap.org/portal/interactive). A score of zero indicates that a gene is not essential. Common essential genes have a median score of -1. A lower score indicates that a gene is more likely to be dependent in a given cell line.

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ARTICLE ABSTRACT

Nucleophosmin (NPM1) is frequently mutated in acute myeloid leukemia, and NPM1 expression is elevated in several cancer types. NPM1 is a multifunctional oligomeric protein involved in numerous cellular functions that include participating in liquid-liquid phase separation, ribosome biogenesis, chaperoning of histones, and modulation of transcription. In this review, we discuss the underappreciated role of NPM1 in DNA damage repair, specifically PolĪ·-mediated translesion synthesis, base excision, and homologous recombination and highlight the therapeutic potential of NPM1 targeting in cancer treatment.

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