Supplementary Table 9 from Tracking Nongenetic Evolution from Primary to Metastatic ccRCC: TRACERx Renal

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posted on 2025-03-03, 08:21 authored by Ángel Fernández-Sanromán, Annika Fendler, Benjy J.Y. Tan, Anne-Laure Cattin, Charlotte Spencer, Rachael Thompson, Lewis Au, Irene Lobon, Husayn Ahmed Pallikonda, Alice Martin, Fiona Byrne, Antonia Franz, Anna Mikolajczak, Haseeb Rahman, Zayd Tippu, Scott T.C. Shepherd, Hugang Feng, Daqi Deng, Andrew Rowan, Lisa Pickering, Andrew J.S. Furness, Kate Young, David Nicol, Sarah Maria Rudman, Tim O’Brien, Kim Edmonds, Ashish Chandra, Steve Hazell, Kevin Litchfield, George Kassiotis, James Larkin, Samra Turajlic

Supplementary Table 9. Univariate Cox regression results for progression-free survival in the TRACERx Renal cohort based on the expression of each of 613 HERV/LTR elements.

Funding

“la Caixa” Foundation (“la Caixa”)

Cancer Research UK (CRUK)

HORIZON EUROPE European Research Council (ERC)

Rosetrees Trust (Rosetrees)

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ARTICLE ABSTRACT

Using joint genomic–transcriptomic analysis of 243 samples, we reveal recurrent patterns of nongenetic evolution in ccRCC not exclusively governed by genetic factors, including T-cell depletion, tumor T-cell receptor coevolution, potential cGAS–STING repression, and increased cell proliferation. These patterns can aid clinical management and guide novel treatment approaches.

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Keywords

Biomarkers Prognostic biomarkers Genitourinary Cancers Renal cancer Progression, Invasion & Metastasis Metastasis Tumor Evolution Tumor Heterogeneity Tumor Microenvironment

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