Supplementary Table 9 from The Germline and Somatic Origins of Prostate Cancer Heterogeneity

dataset

posted on 2025-05-02, 07:24 authored by Takafumi N. Yamaguchi, Kathleen E. Houlahan, Helen Zhu, Natalie Kurganovs, Julie Livingstone, Natalie S. Fox, Jiapei Yuan, Jocelyn Sietsma Penington, Chol-Hee Jung, Tommer Schwarz, Weerachai Jaratlerdsiri, Job van Riet, Peter Georgeson, Stefano Mangiola, Kodi Taraszka, Robert Lesurf, Jue Jiang, Ken Chow, Lawrence E. Heisler, Yu-Jia Shiah, Susmita G. Ramanand, Michael J. Clarkson, Anne Nguyen, Shadrielle Melijah G. Espiritu, Ryan Stuchbery, Richard Jovelin, Vincent Huang, Connor Bell, Edward O’Connor, Patrick J. McCoy, Christopher M. Lalansingh, Marek Cmero, Adriana Salcedo, Eva K.F. Chan, Lydia Y. Liu, Phillip D. Stricker, Vinayak Bhandari, Riana M.S. Bornman, Dorota H.S. Sendorek, Andrew Lonie, Stephenie D. Prokopec, Michael Fraser, Justin S. Peters, Adrien Foucal, Shingai B.A. Mutambirwa, Lachlan Mcintosh, Michèle Orain, Matthew Wakefield, Valérie Picard, Daniel J. Park, Hélène Hovington, Michael Kerger, Alain Bergeron, Veronica Sabelnykova, Ji-Heui Seo, Mark M. Pomerantz, Noah Zaitlen, Sebastian M. Waszak, Alexander Gusev, Louis Lacombe, Yves Fradet, Andrew Ryan, Amar U. Kishan, Martijn P. Lolkema, Joachim Weischenfeldt, Bernard Têtu, Anthony J. Costello, Vanessa M. Hayes, Rayjean J. Hung, Housheng H. He, John D. McPherson, Bogdan Pasaniuc, Theodorus van der Kwast, Anthony T. Papenfuss, Matthew L. Freedman, Bernard J. Pope, Robert G. Bristow, Ram S. Mani, Niall M. Corcoran, Jüri Reimand, Christopher M. Hovens, Paul C. Boutros

Supplementary Table 9 summarizes the characterization of 16 SNPs associated with 23 concordant dQTLs.

Funding

National Cancer Institute (NCI)

United States Department of Health and Human Services

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DOD Prostate Cancer Research Program (PCRP)

History

ARTICLE ABSTRACT

This study uncovered 223 recurrently mutated driver regions using the largest cohort of prostate tumors to date. It reveals associations between germline SNPs, somatic drivers, and tumor aggression, offering significant insights into how prostate tumor evolution is shaped by germline factors and the timing of somatic mutations.