posted on 2023-05-18, 14:20authored byChun-Miao Deng, Guo-Geng Zhang, Qin-Wen Liu, Jiao-Jiao Xu, Zhi-Chao Liu, Jing Yang, Tao-Yang Xu, Zhi-Gang Li, Fan Zhang, Bin Li
Supplementary Table 9 shows Top 30 cytokines upregulated in the CM from fibroblasts cultured with CM-ANO1 compared with CM-CON
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ARTICLE ABSTRACT
Metastatic cancer cells upregulate ANO1 to activate cell-intrinsic and -extrinsic mechanisms that alter cholesterol metabolism and stimulate fibroblasts, which can be targeted with ANO1 inhibitors to inhibit metastatic growth.See related commentary by Singh and Mehla, p. 1759