American Association for Cancer Research
19406207capr170356-sup-191914_2_supp_5218045_pjlfgb.xlsx (49.39 kB)

Supplementary Table 4 from JAK3 Variant, Immune Signatures, DNA Methylation, and Social Determinants Linked to Survival Racial Disparities in Head and Neck Cancer Patients

Download (49.39 kB)
posted on 2023-04-03, 21:42 authored by Rafael Guerrero-Preston, Fahcina Lawson, Sebastian Rodriguez-Torres, Maartje G. Noordhuis, Francesca Pirini, Laura Manuel, Blanca L. Valle, Tal Hadar, Bianca Rivera, Oluwasina Folawiyo, Adriana Baez, Luigi Marchionni, Wayne M. Koch, William H. Westra, Young J. Kim, James R. Eshleman, David Sidransky

Cox regression analysis of TCGA Head and Neck Squamous Cell Carcinoma patients (n=279).



National Institute of Dental and Craniofacial Research

Head and Neck Cancer SPORE

National Cancer Institute

Find out more...



To inform novel personalized medicine approaches for race and socioeconomic disparities in head and neck cancer, we examined germline and somatic mutations, immune signatures, and epigenetic alterations linked to neighborhood determinants of health in Black and non-Latino White (NLW) patients with head and neck cancer. Cox proportional hazards revealed that Black patients with squamous cell carcinoma of head and neck (HNSCC) with PAX5 (P = 0.06) and PAX1 (P = 0.017) promoter methylation had worse survival than NLW patients, after controlling for education, zipcode, and tumor–node–metastasis stage (n = 118). We also found that promoter methylation of PAX1 and PAX5 (n = 78), was correlated with neighborhood characteristics at the zip-code level (P < 0.05). Analyses also showed differences in the frequency of TP53 mutations (n = 32) and tumor-infiltrating lymphocyte (TIL) counts (n = 24), and the presence of a specific C → A germline mutation in JAK3, chr19:17954215 (protein P132T), in Black patients with HNSCC (n = 73; P < 0.05), when compared with NLW (n = 37) patients. TIL counts are associated (P = 0.035) with long-term (>5 years), when compared with short-term survival (<2 years). We show bio-social determinants of health associated with survival in Black patients with HNSCC, which together with racial differences shown in germline mutations, somatic mutations, and TIL counts, suggests that contextual factors may significantly inform precision oncology services for diverse populations.

Usage metrics

    Cancer Prevention Research



    Ref. manager