Supplementary Table 4 from High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis

Name: Supplementary Table 4 from High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis
Published: 2024-11-11T09:40:13+00:00
License: https://creativecommons.org/licenses/by/4.0/
Keywords: cancer

https://doi.org/10.1158/2767-9764.27646295

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posted on 2024-11-11, 09:40 authored by Annie Wai Yeeng Chai, Yee Hua Tan, Shiyin Ooi, Pei San Yee, Shi Mun Yee, Howard Lightfoot, Syd Barthorpe, Mathew J. Garnett, Sok Ching Cheong

<p>ln IC50 data of 339 compounds in 21 OSCC cell lines</p>

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DOI - Is supplement to High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis

ARTICLE ABSTRACT

Mechanistically guided drug repurposing has been made possible by systematically integrating pharmacologic and CRISPR-Cas9 screen data. Our study discovers the biomarker and cell death mechanisms underpinning sensitivity toward AZD5582, an antagonist of the inhibitor of apoptosis family protein. Our findings have important implications for improving future trial design for patients with OSCC using this emerging drug class.

Supplementary Table 4 from High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis

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