American Association for Cancer Research

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Supplementary Table 3 from Protein Kinase C Alpha is a Central Node for Tumorigenic Transcriptional Networks in Human Prostate Cancer

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posted on 2023-04-04, 01:44 authored by Mariana Cooke, Xuyao Zhang, Suli Zhang, Evgeniy Eruslanov, Priti Lal, Reba E. Daniel, Michael D. Feldman, Martin C. Abba, Marcelo G. Kazanietz

Gene Set Enrichment analysis (GSEA) of transcription factor binding sites (TFBS).


HHS | NIH | National Cancer Institute (NCI)

Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación (National Agency for the Promotion of Research, Technological Development and Innovation)



PKCα was found to be aberrantly expressed in human prostate cancer. Silencing the expression of this kinase from aggressive prostate cancer cell lines reduces their proliferative, tumorigenic, and invasive properties. In addition, our findings implicate PKCα as a major node for transcriptional regulation of tumorigenic, inflammatory, and EMT networks in prostate cancer, highlighting its potential relevance as a therapeutic target.