Supplementary Table 2 from Tumor Expression of CD83 Reduces Glioma Progression and Is Associated with Reduced Immunosuppression

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posted on 2025-04-03, 21:41 authored by Malcolm F. McDonald, Rachel Naomi Curry, Isabella O’Reilly, Brittney Lozzi, Alexis Cervantes, Zhung-Fu Lee, Anna Rosenbaum, Peihao He, Carrie Mohila, Arif O. Harmanci, Akdes Serin Harmanci, Benjamin Deneen, Ganesh Rao

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DOI - Is supplement to Tumor Expression of CD83 Reduces Glioma Progression and Is Associated with Reduced Immunosuppression

ARTICLE ABSTRACT

Immunosuppression in malignant glioma remains a barrier to therapeutic development. CD83 overexpression in human and mouse glioma increases survival. CD83+ tumor cells promote signatures related to cytotoxic T cells, enhanced activation of CD8+ T cells, and increased proinflammatory cytokines. These findings suggest that tumor-expressed CD83 could mediate tumor–immune communications.

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Keywords

CNS Cancers Gliomas, Glioblastomas Tumor Microenvironment Immune cells and the microenvironment Cytokines and the microenvironment Computational Methods Gene expression profiling Sequence analysis Immunology

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