sorry, we can't preview this file

crc-22-0170-s08.xlsx (146.5 kB)

Supplementary Table 2 from Protein Kinase C Alpha is a Central Node for Tumorigenic Transcriptional Networks in Human Prostate Cancer

dataset

posted on 2023-04-04, 01:44 authored by Mariana Cooke, Xuyao Zhang, Suli Zhang, Evgeniy Eruslanov, Priti Lal, Reba E. Daniel, Michael D. Feldman, Martin C. Abba, Marcelo G. Kazanietz

Pathway and GO enrichment analysis.

Funding

HHS | NIH | National Cancer Institute (NCI)

Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación (National Agency for the Promotion of Research, Technological Development and Innovation)

History

ARTICLE ABSTRACT

PKCα was found to be aberrantly expressed in human prostate cancer. Silencing the expression of this kinase from aggressive prostate cancer cell lines reduces their proliferative, tumorigenic, and invasive properties. In addition, our findings implicate PKCα as a major node for transcriptional regulation of tumorigenic, inflammatory, and EMT networks in prostate cancer, highlighting its potential relevance as a therapeutic target.

Usage metrics

Keywords

Cell Signaling Protein serine-threonine kinases Computational Methods Gene expression profiling Genitourinary Cancers Prostate cancer Progression, Invasion & Metastasis

Licence

CC BY

Exports

RefWorks

BibTeX

Ref. manager

Endnote

DataCite

NLM