American Association for Cancer Research
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Supplementary Table 2 from Initial Whole-Genome Sequencing of Plasma Cell Neoplasms in First Responders and Recovery Workers Exposed to the World Trade Center Attack of September 11, 2001

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posted on 2023-03-31, 23:03 authored by Francesco Maura, Benjamin Diamond, Kylee H. Maclachlan, Andriy Derkach, Venkata D. Yellapantula, Even H. Rustad, Malin Hultcrantz, Urvi A. Shah, Jessica Hong, Heather J. Landau, Christine A. Iacobuzio-Donahue, Elli Papaemmanuil, Shani Irby, Laura Crowley, Michael Crane, Mayris P. Webber, David G. Goldfarb, Rachel Zeig-Owens, Orsi Giricz, Amit Verma, David J. Prezant, Ahmet Dogan, Sohrab P. Shah, Yanming Zhang, Ola Landgren

Supplementary Table 2. Mutational signature profiles for 5 environmental agents detected in the WTC debris (Kucab et al, Cell 2019).

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Sylvester Comprehensive Cancer Center

Memorial Sloan Kettering Cancer Center

American Society of Hematology, the International Myeloma Foundation

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ARTICLE ABSTRACT

The World Trade Center (WTC) attack of September 11, 2001 created an unprecedented environmental exposure to known and suspected carcinogens. High incidence of multiple myeloma and precursor conditions has been reported among first responders to the WTC disaster. To expand on our prior screening studies, and to characterize the genomic impact of the exposure to known and potential carcinogens in the WTC debris, we were motivated to perform whole-genome sequencing (WGS) of WTC first responders and recovery workers who developed a plasma cell disorder after the attack. We performed WGS of nine CD138-positive bone marrow mononuclear samples from patients who were diagnosed with plasma cell disorders after the WTC disaster. No significant differences were observed in comparing the post-WTC driver and mutational signature landscapes with 110 previously published WGSs from 56 patients with multiple myeloma and the CoMMpass WGS cohort (n = 752). Leveraging constant activity of the single-base substitution mutational signatures 1 and 5 over time, we estimated that tumor-initiating chromosomal gains were windowed to both pre- and post-WTC exposure. Although limitations in sample size preclude any definitive conclusions, our findings suggest that the observed increased incidence of plasma cell neoplasms in this population is due to complex and heterogeneous effects of the WTC exposure that may have initiated or contributed to progression of malignancy.

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