posted on 2023-04-04, 01:44authored byMariana Cooke, Xuyao Zhang, Suli Zhang, Evgeniy Eruslanov, Priti Lal, Reba E. Daniel, Michael D. Feldman, Martin C. Abba, Marcelo G. Kazanietz
Differentially expressed genes in PKCalpha silenced PC3 cells.
Funding
HHS | NIH | National Cancer Institute (NCI)
Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación (National Agency for the Promotion of Research, Technological Development and Innovation)
History
ARTICLE ABSTRACT
PKCα was found to be aberrantly expressed in human prostate cancer. Silencing the expression of this kinase from aggressive prostate cancer cell lines reduces their proliferative, tumorigenic, and invasive properties. In addition, our findings implicate PKCα as a major node for transcriptional regulation of tumorigenic, inflammatory, and EMT networks in prostate cancer, highlighting its potential relevance as a therapeutic target.