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Supplementary File 2 from Repurposing Itraconazole and Hydroxychloroquine to Target Lysosomal Homeostasis in Epithelial Ovarian Cancer

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posted on 2023-04-04, 01:22 authored by Stefano Marastoni, Ainhoa Madariaga, Aleksandra Pesic, Sree Narayanan Nair, Zhu Juan Li, Zvi Shalev, Troy Ketela, Ilaria Colombo, Victoria Mandilaras, Michael Cabanero, Jeff P. Bruce, Xuan Li, Swati Garg, Lisa Wang, Eric X. Chen, Sarbjot Gill, Neesha C. Dhani, Wenjiang Zhang, Melania Pintilie, Valerie Bowering, Marianne Koritzinsky, Robert Rottapel, Bradly G. Wouters, Amit M. Oza, Anthony M. Joshua, Stephanie Lheureux

CRISPR screen TOV1946. Results of the Itra sensitizing CRISPR screen on the TOV1946 cell line using drugZ algorithm.

Funding

Government of Ontario (Ontario Government)

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ARTICLE ABSTRACT

The combination of the antifungal drug itraconazole with antimalarial drug hydroxychloroquine leads to a cytotoxic lysosomal dysfunction, supporting the rational for further research on lysosomal targeting in ovarian cancer.

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    Cancer Research Communications

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    Keywords

    Small Molecule AgentsDrug TargetsDrug MechanismsDrug-mediated stimulation of cell death pathwaysTranslational ResearchClinical Trial ResultsPhase I clinical trialsGynecological CancersOvarian cancerChemotherapyCombination chemotherapy

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