Supplemental Table S2 from Reactive Oxygen Species Drive Proliferation in Acute Myeloid Leukemia via the Glycolytic Regulator PFKFB3

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posted on 2023-03-31, 03:48 authored by Andrew J. Robinson, Goitseone L. Hopkins, Namrata Rastogi, Marie Hodges, Michelle Doyle, Sara Davies, Paul S. Hole, Nader Omidvar, Richard L. Darley, Alex Tonks

Statistically significant biochemicals profiled in this study.

Funding

Tenovus Cancer Care

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Medical Research Council

Health and Care Research Wales

European Regional Development Fund

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ARTICLE ABSTRACT

These findings show that ROS generated by NOX2 in AML cells promotes glycolysis by activating PFKFB3 and suggest PFKFB3 as a novel therapeutic target in AML.

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Keywords

Biochemistry Cell Death And Senescence Survival factors Cell Signaling Gene Technologies Microarrays Hematological Cancers Leukemias Protein Technologies Small Molecule Agents

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CC BY

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