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Related Articles from Enhancing Cancer Vaccine Efficacy via Modulation of the Tumor Microenvironment

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posted on 2023-03-31, 15:41 authored by Mary L. Disis
Related Articles from Enhancing Cancer Vaccine Efficacy via Modulation of the Tumor Microenvironment

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ARTICLE ABSTRACT

The development of therapeutic cancer vaccines is impacted by immunosuppressive elements in the tumor microenvironment. Most immunogenic cancer proteins are “self,” therefore, peripheral tolerance contributes substantially to tumor immune escape. Transforming growth factor β (TGFβ) actively modulates both inflammation and tolerance induction. Combining vaccination with agents that disarm TGFβ will enhance vaccine efficacy. (Clin Cancer Res 2009;15(21):1–3) (Clin Cancer Res 2009;15(21):6476–8)

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    Clinical Cancer Research

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    CarcinogenesisDNA damage and repairImmunologyImmunotherapyCancer vaccines

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