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Related Article from Pertuzumab Protects the Achilles' Heel of Trastuzumab—Emtansine

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posted on 2023-03-31, 17:26 authored by William R. Gwin, Neil L. Spector

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ARTICLE ABSTRACT

Trastuzumab emtansine (T-DM1) represents a significant advancement in the treatment of HER2+ breast cancers. Its clinical efficacy however will be limited by the development of therapeutic resistance. In this report, the HER3 ligand neuregulin is shown to mediate T-DM1 resistance, which was overcome by administration of pertuzumab, a steric inhibitor of HER2 dimerization. Clin Cancer Res; 20(2); 278–80. ©2013 AACR.