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Related Article from Personalized Tamoxifen: A Step Closer but Miles To Go

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posted on 2023-03-31, 16:00 authored by Aditya Bardia, Vered Stearns
Related Article from Personalized Tamoxifen: A Step Closer but Miles To Go

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    DOI - Is supplement to Personalized Tamoxifen: A Step Closer but Miles To Go

ARTICLE ABSTRACT

Genetic variants in CYP2D6 lead to reduced conversion of tamoxifen to the active metabolite endoxifen. However, the role of the CYP2D6 genotype in predicting tamoxifen-associated outcomes remains controversial. Accurate assignment of the CYP2D6 genotype in archival tissues is crucial for future studies attempting to determine risk prediction of outcomes in tamoxifen-treated individuals. Clin Cancer Res; 16(17); 4308–10. ©2010 AACR.

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    Clinical Cancer Research

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    Breast CancerPharmacologyPharmacogenetics/pharmacogenomics

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