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Related Article from Personalized Tamoxifen: A Step Closer but Miles To Go

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posted on 2023-03-31, 16:00 authored by Aditya Bardia, Vered Stearns
Related Article from Personalized Tamoxifen: A Step Closer but Miles To Go

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ARTICLE ABSTRACT

Genetic variants in CYP2D6 lead to reduced conversion of tamoxifen to the active metabolite endoxifen. However, the role of the CYP2D6 genotype in predicting tamoxifen-associated outcomes remains controversial. Accurate assignment of the CYP2D6 genotype in archival tissues is crucial for future studies attempting to determine risk prediction of outcomes in tamoxifen-treated individuals. Clin Cancer Res; 16(17); 4308–10. ©2010 AACR.

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    Clinical Cancer Research

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    Breast CancerPharmacologyPharmacogenetics/pharmacogenomics

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