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Related Article from It Takes Two to Tango: Dual Inhibition of PI3K and MAPK in Rhabdomyosarcoma

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posted on 2023-03-31, 17:31 authored by Arman Jahangiri, William A. Weiss

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ARTICLE ABSTRACT

The PI3K/AKT/mTOR and RAS/RAF/MAPK pathways play essential roles in rhabdomyosarcoma. Singular targeting of each pathway is ineffective due to extensive cross-talk and compensatory feedback between these two pathways. Dual blockade with inhibitors of PI3K and MAPK in combination synergistically inhibits growth of rhabdomyosarcoma both in vitro and in vivo. Clin Cancer Res; 19(21); 5811–3. ©2013 AACR.