Related Article from Inclusion of Patients with Brain Metastases in Phase I Trials: An Unmet Need
ARTICLE ABSTRACT
Patients with brain metastases are increasing in number; however, these patients are often excluded in phase I/II trials due to perceived poor prognosis, risk of hemorrhage, inefficient drug delivery, and confounding toxicities. Tsimberidou and colleagues demonstrate that selected patients can be appropriately enrolled in phase I trials and have outcomes representative of the general cancer population. Clin Cancer Res; 17(12); 3855–7. ©2011 AACR.
