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Related Article from Does PTEN Loss Impair DNA Double-Strand Break Repair by Homologous Recombination?
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posted on 2023-03-31, 16:42 authored by Clayton R. Hunt, Arun Gupta, Nobuo Horikoshi, Tej K. PanditaRelated Article from Does PTEN Loss Impair DNA Double-Strand Break Repair by Homologous Recombination?
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ARTICLE ABSTRACT
The tumor suppressor PTEN is frequently lost in cancer cells, resulting in altered radiation and drug sensitivity. However, the role of PTEN in DNA repair is controversial. Detailed studies in prostate cancer cells now indicate PTEN does not regulate RAD51 expression or homologous recombination and is not a biomarker for PARP inhibitor sensitivity. Clin Cancer Res; 18(4); 920–2. ©2011 AACR.Usage metrics
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