Related Article from Does Lapatinib Work against HER2-negative Breast Cancers?

Name: Related Article from Does Lapatinib Work against HER2-negative Breast Cancers?
Published: 2023-03-31T16:04:39+00:00
License: https://creativecommons.org/licenses/by/4.0/
Keywords: Breast Cancer

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posted on 2023-03-31, 16:04 authored by Ingrid A. Mayer, Carlos L. Arteaga

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ARTICLE ABSTRACT

Aberrant growth factor receptor signaling can augment or suppress estrogen receptor (ER) function in hormone-dependent breast cancer cells and lead to escape from anti-estrogen therapy. Interruption of HER2/ER cross-talk with lapatinib can restore sensitivity to anti-estrogens and thus, should be investigated in combination with endocrine therapy in patients with ER+/HER2-negative breast cancers. Clin Cancer Res; 16(5); 1355–7