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Extended Dataset 1 from DDR2 Coordinates EMT and Metabolic Reprogramming as a Shared Effector of FOXQ1 and SNAI1

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posted on 2023-04-04, 01:45 authored by Allison V. Mitchell, Jason Wu, Fanyan Meng, Lun Dong, C. James Block, Won-min Song, Bin Zhang, Jing Li, Guojun Wu

Common deregulated genes between HMLE_FOXQ1 and HMLE_SNAIL1 cell lines

Funding

HHS | NIH | National Cancer Institute (NCI)

Barbara Ann Karmanos Cancer Institute (BAKCI)

HHS | National Institutes of Health (NIH)

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ARTICLE ABSTRACT

The critical role of DDR2 in cancer metastasis has been well established. However, the exact function of DDR2 in driving cancer metastatic progression remains unclear. The results of our current study provide new insights into the cancer-driving function of DDR2, suggesting that DDR2, as a shared effector of the EMT program, may drive tumor progression by promoting breast cancer cell motility and metabolic reprogramming.

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Keywords

Metabolism Metabolic pathways Oncogenes & Tumor Suppressors Oncogenes Breast Cancer Gene Regulation Oncogenic transcription factors

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CC BY

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