posted on 2023-04-04, 01:45authored byAllison V. Mitchell, Jason Wu, Fanyan Meng, Lun Dong, C. James Block, Won-min Song, Bin Zhang, Jing Li, Guojun Wu
Common deregulated genes between HMLE_FOXQ1 and HMLE_SNAIL1 cell lines
Funding
HHS | NIH | National Cancer Institute (NCI)
Barbara Ann Karmanos Cancer Institute (BAKCI)
HHS | National Institutes of Health (NIH)
History
ARTICLE ABSTRACT
The critical role of DDR2 in cancer metastasis has been well established. However, the exact function of DDR2 in driving cancer metastatic progression remains unclear. The results of our current study provide new insights into the cancer-driving function of DDR2, suggesting that DDR2, as a shared effector of the EMT program, may drive tumor progression by promoting breast cancer cell motility and metabolic reprogramming.